age-related reduction of myocardial metabolic efficiency: is it time to routinely measure myocardial metabolism to monitor cardiac health? - home energy storage
Age-
Related decrease in normal myocardial metabolism reserve of cardiac cells, high-
Energy phosphate compound ATP and phosphate re-atine (PCr)
It is strictly controlled on a series of properties, because ATP produced by mitochondrial oxidation and phosphorus is closely related to ATP utilization of the cellular triphosphate enzyme.
ATP is a direct source of energy-
The reaction is consumed in cells, while PCr is used as an energy storage compound, in addition, as a "ck kinase-
PCr energy shuttle.
Clinical study of previous use of phosphorus
31 magnetic resonance spectrum (31P-MRS)
To measure the PCr/ATP ratio in the human heart muscle, it has been shown that this ratio is reduced in high blood pressure and, more importantly, in the failed human heart muscle.
In their cardiac manuscripts, Nathania1 examined the possibility of age, PCr/ATP ratio, and heart strength in healthy women through 31 P spectrum and heart MRS tested for maximum graded cardio-pulmonary exercise
Compared with the youth group, PCr/ATP ratio, peak cardiac power, cardiac contraction function and peak exercise oxygen consumption were significantly reduced in the elderly group.
The PCr/ATP ratio was significantly positively correlated with the function of cardiac contraction, peak power output and peak oxygen consumption.
These results show that high
The energy phosphate metabolism and peak power of the heart decreased with age.