early life stress can modify dna expression, a study finds - home energy storage
A Bengaluru-
Researchers based on the study team found a link between early stress and problems, externalizing the behavior in the DNA of the child of the alcoholic parent.
In particular, they studied the children of 50 alcoholic parents who experienced stress in the early days, including the violent behavior of alcoholic fathers against mothers and families, and even sometimes they had to leave home.
They also studied 50 healthy children in a control group without this medical history.
The results of this study were published in the journal Progress in neuropsychiatric pharmacology and Biological Psychiatry.
As we all know, there are several biological effects in biology and adversity every year.
One of them is DNA methylation.
The process of chemical changes in DNA molecules.
It also affects the function of the so-called lower part of the visual Hill. pituitary axis.
This is a complex set of interactions between the lower visual Hill of the brain and the anterior lobe of the brain and adrenaline (
Above the kidney).
"Visual Hill-
The brain motor axis is the main endocrine system that controls stress response, regulates digestion, immune system, mood and mood, sex, energy storage and consumption, "Meera Purushottam, Laboratory of Molecular Genetics, Department of Psychiatry, National Institute of Mental Health and neuroscience, explains (NIMHANS)
Bangalore is also the author of this paper.
This study provides further evidence of early adversity and decreased cortisol activity, increased site-in children with alcohol liquor-
Specific DNA methylation in a specific gene (SLC6A4)
And highly externalized behavior.
"Gene encoding of the five serotonin transporter.
Serotonin is a very important chemical produced in the body and is a necessary condition for communication between neurons, "said Dr. Purushottam.
The activity of this protein is essential for appetite, emotional health, cognition and memory.
In the course of the study, the children were subjected to standard stress tests, their saliva was sampled every ten minutes, and a level of chemical called cortical steroids was tested.
In normal individuals, it is expected that the level of cortical hormone will rise during stress.
"We found that in children with chronic stress, there was a slight increase in cortical hormone levels when exposed to acute stress," said Vivek Benegal and a colleague from the NIMHANS addiction medical center.
The author of the paper.
The collated data this study is unique in that it performs a detailed assessment of the functions of the baipa axis by cortisol estimates during stress and estimates the chemical effects of early adversity at DNA levels.
This combined approach helped researchers estimate adversity, the function of the baipa axis, DNA methylation, and behavior.
"Putting all the data in the same sample set helps us to conclude how the four parameters interact," she said . ".
The study concluded that the children of alcohol drinkers may have impaired paella and epigenetic changes at DNA levels, which may lead to an increase in external behavior.